Role Of The Doseresponse Relationship

In microbial risk assessment, the dose-response relationship is the function that connects the anticipated pattern of exposure to the expected level of adverse effect. In generic terms, the expected proportion of a population that will experience a risk of a particular outcome (p) is written as a function of the average dose (d) administered to that population, that is,

Hence, the pattern of exposure must be characterized as an input, and the particular outcome or outcomes that are desired to be estimated must be stated. Whereas for some pathogens, dose-response information is available from human trials (i.e., volunteer subjects fed controlled levels of organisms), for other pathogens only animal data are available. Even if human feeding study data exist, the residual level of risk desired for public health protection is far below the lowest dose used, and hence a dose-response model must be relied upon to provide this extrapolation.

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