This book covers the use of short tandem repeat DNA markers for human identity testing (see D.N.A. Box 2.2). These markers have become popular for forensic DNA typing because they are PCR-based and work with low-quantity DNA templates or degraded DNA samples. STR typing methods are amenable to automation and involve sensitive fluorescent detection, which enables scientists to collect data quickly from these markers. When sites on multiple chromosomes are examined, STRs are highly discriminating between unrelated and even closely related individuals. Finally, discrete alleles make results easier to interpret and to compare through the use of computerized DNA databases than RFLP-based systems where similar DNA sizes were grouped together.
Web sites with additional Short Tandem Repeat Internet Database (STRBase) with details on STR typing information on forensic http://www.cstl.nist.gov/biotech/strbase
Denver District Attorney's Office (court case summaries involving DNA testing) http://www.denverda.org
American Prosecutors Research Institute (information to help in prosecuting
Smith Alling Lane web site on policies impacting forensic DNA typing http://www.dnaresource.com
National Institute of Justice (NIJ) with funding opportunities http://www.ojp.usdoj.gov/nij
FBI's Combined DNA Index System (CODIS)
Forensic Science Service
Cantor, C.R. and Smith, C.L. (1999) Genomics: The Science and Technology Behind the Human Genome Project. New York: John Wiley & Sons.
Kreeger, L.R. and Weiss, D.M. (2003) Forensic DNA Fundamentals for the Prosecutor: Be Not Afraid. Alexandria, Virginia: American Prosecutors Research Institute. Available online at: http://www.ndaa-apri.org/publications/apri/dna_pubs.html.
Lee, H.C., Ladd, C., Bourke, M.T., Pagliaro, E. and Tirnady, F. (1994) American Journal of Forensic Medicine and Pathology, 15, 269-282.
National Research Council (1996) The Evaluation of Forensic DNA Evidence. Washington, DC: National Academy Press.
Primrose, S.B. (1998) Principles of Genome Analysis: A Guide to Mapping and Sequencing DNA from Different Organisms, 2nd edn. Malden, MA: Blackwell Science.
Tagliaferro, L. and Bloom, M.V. (1999) The Complete Idiot's Guide to Decoding Your Genes. New York: Alpha Books.
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