If the genomic DNA in a sample is severely degraded or PCR inhibitors are present, only a partial STR profile may be obtained (see Chapter 7). Usually the larger STR loci in a multiplex reaction, such as D18S51 and FGA, will be the first to fail on a degraded DNA sample. When only a partial profile is obtained, the significance of a match will go down because there are not as many loci to compare (see Chapter 22). However, the use of mini-plex STR systems with smaller PCR product sizes than those used in commercial STR kits can be used to recover information lost at the larger loci (Butler et al. 2003).
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This book discusses the futility of curing stammering by common means. It traces various attempts at curing stammering in the past and how wasteful these attempt were, until he discovered a simple program to cure it. The book presents the life of Benjamin Nathaniel Bogue and his struggles with the handicap. Bogue devotes a great deal of text to explain the handicap of stammering, its effects on the body and psychology of the sufferer, and its cure.