A

Abbott, 386, 388

Adsorption rate coefficient, time-dependent, 30-31, 42 decreasing, 31-32 fractal kinetics and, 70, 76-78 increasing, 32 Adsorption rate coefficient, variable (binding),

30-31, 51-54 Aequorin, use of, 281-282 Affinity Sensors, 17, 386 Affymetrix, 392 Allometric scaling laws, 72 Amino silanization, 224-225 Amperometric biosensors, 18 Analyte concentration in solution, effects of, 90-102

Analyte-receptor binding in cells binding of chlorophenol to Bacillus stearothermphillus, 336-341 binding of 500 nM mutant forms to salivary agglutinin, 319-322 binding of glycoprotein-D of herpes simplex virus, 331-336 binding of R18-labeled human erythrocytes

(RBCs), 326-331 binding of wild-type fragment to salivary agglutinin, 321, 323-326 binding rate coefficient, 318-319 conclusions, 341

dual-fractal analysis, 314 fractal dimension, influence of, 319 results, 315-341 role of, 311-313 single-fractal analysis, 313-314 Streptococcus mutans to salivary agglutinin, 315-318 Anti-/?-galactosidase, 378-379 Antibody in solution/antigen on the surface, 55-60

Antigen-antibody binding kinetics, diffusional limitations and lateral interactions on conclusions, 63-65

influence of lateral interactions, 46-51, 57-60

multivalency antibodies for large antigen systems, 60-63 second-order reaction kinetics, 55-57 variable adsorption rate coefficient, 30-31, 51-54

Antigen-antibody binding kinetics, diffusional limitations and reaction order on diffusional limitations, affects of, 23 one-and-one-half-order reaction kinetics, 38-43

second-order reaction, 32-38 theoretical model, 24-32 Antigen-antibody imbolization, 6-7 Antigen in solution/antibody on the surface, 46-51

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