B

Bacillus stearothermpkillus, 336-341 Bayer, 386

B-DPPE and B-X-DPPE, 102 BIACORE biosensor, 17, 90, 128, 147-150, 187, 345, 347, 386, 390-392 measurement errors and nonspecific binding, 229-230 Binding phase, fractal dimensions and analyte concentration in solution, effects of, 90-102

background information, 84-85 different surfaces, effects of, 102-116 dual-fractal analysis, 87-88 rate of binding, obtaining, 88 regeneration, effects of, 116-118 single-fractal analysis, 86 summary and conclusions, 122-123 Binding rate coefficient, fractal dimensions and antibody FITC/biotinylated indium-tin oxide (1TO), 144 conclusions, 183-184 dual-fractal analysis, 132-133 dual-fractal analysis, results of, 160-183 Fab fragment, 179-183 Helicobacter pylori, 133-142 hepatitis, 160-161 IgG, 150-154 IgG-FITC, 161-162 interferon, 142 L-adenosineF1TC, 144 ligand-analyte pairs, 147-148 lipopolysaccharide (LPS), 163, 166-169 Mab, 148-149 mFab, 150

nicotinic acetylcholine receptor, 144-145 oligonuclotides, 154-155, 156 polymerase chain-reaction-amplified DNA,

116-121, 169-173 RNA, high-affinity, 142, 144, 177-179 single-fractal analysis, 132 single-fractal analysis, results of, 133-160 surface plasmon resonance and, 349—379

thrombin, 155, 157-160 trichloroethylene, 173-176 variable coefficient, 130-133 Binding rate coefficients regeneration, effects of, 116-121 Biomedical applications, 17-19 Biomolecular interaction analysis (BIA),

287-288 Bioprocess monitoring, 229 Biosensors applications for, 13-17, 127-128, 187, 385,

393-395 assay formats, 10-12 biomedical applications, 17-19 commercially available, 17 defined, 1

development costs for, 393-396 future for, 396-397 limiting factors, 8-9 major companies making, 386-387 markets for, 386-392 need for, 1-9 problems with, 12-13 specificity and sensitivity properties, 3-6 universities and governmental roles in producing, 387-388 BIOS-1 Sensor, 17 Boehringer Mannheim, 386 bSA concentrations, 362-367

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