N

National Center for Sensor Research (NCSR), 387

Nicotinic acetylcholine receptor optical biosensor, 144-145 Nissin Seifun, 389

Nonspecific binding (NSB), classical analysis attomole-level detection, 225-226 BIACORE binding measurement errors, 229-230

binding steps and theory, 230-232 bioprocess monitoring, 229 carboxy-methylated dextran matrix, 226,227 conclusions, 249-250 creatine kinase and MB form (CK-MB),

222-223 Fab fragments, 223-224 first-order reactions, 232-234 forward binding rate constant, 237-238 forward binding rate constant, time-

dependent, 238-248 immobilization strategies, 226-228 influence of, 237-248

Langmuir-Blodgett (LB) film technique, 224 multianalyte assays and miniaturization, 228-229

one-and-one half-order reactions, 236-237 role of, 221-222 second-order reactions, 234-236 Nonspecific binding (NSB), fractal analysis binding steps and theory, 255-257 conclusions, 269-270 first-order reactions, 257-258 one-and-one half-order reactions, 258-262 polycyclic-aromatic compounds (PACs),

265-269 results, 257-265 role of, 253-254 second-order reactions, 262-265 Nova Biomedical, 18, 386, 396

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