Cumulative Index

Page numbers in boldface type indicate article titles; those in italic type indicate illustrations or caption text. Terms are often defined multiple times; page numbers are given for only the first definition in each volume. The number preceding the colon indicates volume number.

a, defined, 3:212 a-helices conversion to ¡-sheets,

3:188-190, 3:189, 3:190 protein structure role, 3:200-201, 3:203

a-protobacteria, as mitochondrial ancestor, 2:195, 3:57 3, defined, 1:46, 1:216, 3:212 ¡-globin genes, 1:46 ¡-sheets conversion of a-helices,

3:188-190, 3:189, 3:190 protein structure role, 3:200-201, 3:203

AF508 mutation, 1:200, 1:202 2-D PAGE (two-dimensional poly-acrylamide gel electrophoresis), 3:207-208 5-HT1b mice, 1:5

A3243G gene, diabetes and, 3:54 ABI (Applied Biosystems, Inc.), automated sequencers, 1:44-45 ABL1 gene (Abelson murine strain leukemia viral homolog), 1:95 ABMG (American Board of Medical Genetics), clinical geneticist certification, 1:149, 1:150-151 ABO blood group system

Bombay phenotype, 2:8, 2:9 genotypes, 2:128

inheritance patterns, 2:200, 2:207 multiple alleles, 1:83-84, 3:82

Aborigines (Australian), eugenic fitness ranking, 2:17 Acceptor (A) site, in translation, 4:138

Accreditation Council for Graduate Medical Education (ACGME), clinical geneticist certification, 1:150-151 Accutane (isotretinoin), 1:80-81 ACE (angiotensin-converting enzyme), 1:8 Acetaldehyde, and alcoholism, 1:5 Acetylation of DNA, gene repression role, 3:77

of proteins, post-translational, 3:203, 3:205, 4:111 Achondroplasia, 1:75-76, 2:130,

2:131, 2:202 Achromat color vision defects, 1:172 Acidic activation proteins, 2:64, 2:66 Acidity

Archaea adaptations to, 1:36-37 defined, 3:200

impact on protein structure, 3:201

Acids, as chelators, 1:60 Acquired immune deficiency syndrome (AIDS). See HIV/AIDS Acrometageria, progeroid aspects, 1:2

Acrosome cap defined, 4:21 function, 2:35 Acrylamide gels, 1:86, 2:47 ACTH, pituitary gland, 2:160 Actin proteins defined, 2:29

pseudogenes for, 2:30, 3:213 Actinomyces, genome characteristics, 2:116

Activation sites. See Enhancer DNA sequences

Activator proteins, 4:111 AD. See Alzheimer's disease ADA gene, SCID role, 4:75 ADA (Americans with Disabilities Act), genetic discrimination and, 2:93

Adaptation, defined, 4:67 Adaptive radiation, 4:92 Addiction, 1:4-6

and birth defects, 1:77 defined, 1:4

fruit fly models, 1:5-6 inheritance patterns, 1:4-5 rodent models, 1:5 twin studies, 4:162 See also Alcoholism; Smoking (tobacco)

Additive effects of genes, 1:178-179,

1:178 Adenine depurination, 1:240 in DNA alphabet, 2:83, 4:106 and DNA structure, 1:215-220,

1:250-251, 2:50, 2:51, 3:94 evolution of, 2:22-24 mutagenic base analogs, 3:87 origin of term, 1:249 polyadenylated repeats, 2:53, 4:9, 4:145

reactions with aflatoxins, 1:245 in RNA alphabet, 4:46-47, 4:106 structure, 1:216, 3:115, 3:116, 3:118, 3:119, 3:119, 4:47, 4:48, 4:49

See also Base pairs Adeno-associated virus, as gene therapy vector, 2:76 Adenoma, defined, 1:167 Adenoma-carcinoma sequence, 1:167 Adenomatous cells, cancerous tumors, 1:94

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