Initiation of DNA Replication
DNA replication begins (initiates) at special sites called origins of DNA replication. Eukaryotic DNAs each contain multiple replication origins,
- Figure 1. DNA replication begins when ORC proteins attach to an origin of replication, of which there are thousands throughout the genome. Helicase unwinds the double helix, and single-strand binding proteins stabilize it, while it is copied by DNA polymerases.
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