Odoooooc

Reverse transcriptase uses a single-stranded RNA template to create a double-stranded DNA.

-A

T-

-A

T-

-U

A-

-T

A-

-C

G-

-C

G-

-G

C-

->■

-G

C-

-U

A-

-T

A-

-A

T-

-A

T

flow of genetic information from RNA to DNA seemed heretical, and because the experimental techniques needed to test this idea were not yet developed, Temin and his hypothesis were rebuffed for many years.

The biochemical proof for reverse transcription finally arrived in 1970 when two separate research teams, one led by Temin and the other by David Baltimore, simultaneously discovered the elusive RNA-copying DNA polymerase in purified virions. In 1975 Temin and Baltimore shared the Nobel Prize in physiology or medicine for their discovery of reverse transcriptase.

0 0

Post a comment