Ooc

l^M

pol II

TATAA

i TFII - B

TFII - F TFII - E

TFII - H

/ \

Promoter

Coding Region

it to begin transcription. This occurs when TFII-E and -H cooperate to phosphorylate (add a phosphate group to) RNA polymerase. This changes the polymerase's shape sufficiently to allow it to escape the complex of transcription factors and begin transcription.

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