Oooc oc

Inbreeding (continued)

and disease risk, 2:189-190,

2:203, 3:174 founder effect, 2:36-39, 3:174 laws that prevent, 2:189 vs. outcrossing, fitness, 2:146 polymorphisms to study, 3:163 populations studies, 2:190-191 Inbreeding coefficients, defined, 2:190

Inbreeding depression agricultural significance, 2:146 in conservation biology,

1:188-189 explanations for, 2:146-147 polyploidy and, 2:69 Incomplete dominance, 2:200, 3:36 Incomplete penetrance, 2:201, 2:205 Incubating, defined, 1:20 Incyte, gene sequence data, 2:123 Indels (insertion or deletion polymorphisms), 3:160 Indians (American), evolutionary origin, 3:66 Individual genetic variation, 2:191-192

allele scoring strategies, 2:192 alleles and, 2:191-192 alternative splicing and, 1:11-12 among early humans, 3:167-168, 3168

and DNA profiling, 3:192-193 examples, 2:191, 2:192, 2192, 2:202

genetic microchips, 2:119-120, 2:119

Human Genome Project concerns, 2:175 pharmacogenomics applications,

3:144-147 selection and, 4:69 vs. speciation, 4:91-92 Industrial toxins and birth defects, 1:77

and cancer, 1:92

and chromosomal aberrations,

1:119, 1:123 and diabetes, 1:210 and DNA damage, 1:239, 1:242, 3:89

role in disease, 1:214 See also Mutagens Infertility causes of, 4:19-20 chromosomal translocations, 3:97 drugs to treat, 4:19 in male partner, 4:20, 4:21, 4:177 statistics, 4:19

surgical interventions, 4:19 See also Reproductive technology Inflammatory bowel disease, and colon cancer, 1:170 Influenza virus characteristics, 4:165 DNA vaccines, 1:255 pathogenicity of, 2:128 Informants, in pedigree drawing,

3:140-141 Information systems managers,

2:192-194 Informed consent defined, 2:90, 3:218 family studies, 2:168 gene therapy clinical trials, 2:81-82 genetic counselor role, 2:90 genetic testing, 2:102, 3:175 Ingi retrotransposons, 4:145 Ingram, Vernon, 3:95 Inheritance, extranuclear, 2:194-199 of intracellular symbionts, 2:198 plasmids, 2:198, 3:151 significance of, 2:194, 2:198, 3:57 See also Chloroplasts, genome; Mitochondrial genome Inheritance patterns, 2:199-207 anticipation, 2:204-205, 4:150 Arabidopsis research, 1:34-36 biparental, 2:197

blending theory, 3:30, 3:34, 3:102 blood groups, 1:83-84 cartilage matrix protein mutations, 2:132 chromosomal aberrations,

1:120-121, 1:125 complex traits, 1:177-181,

1:213-214, 2:61, 2:206 de novo mutations, 1:120 epistatic interactions, 2:8-9, 2:207

extranuclear, 2195, 2:196-197,

2:204, 2:205 gain-of-function mutations, 3:96 gene-environment interactions,

2:56-57 genetic counselors to explain,

2:88-90, 2:91-92 genetic discrimination, 1:68 growth factor receptor mutations, 2:130 heterozygote advantage,

2:147-148 inbreeding, 2:189-191 incomplete penetrance, 2:201, 2:204

intracellular symbionts, 2:198

in linkage and recombination studies, 3:7-8 loss-of-function genetic mutations, 3:96 mosaicism, 2:204 multifactorial and polygenic,

1:77-78, 2:206, 3:214 natural selection and, 2:26 pedigrees as tools, 3:7, 3:36,

3:138-142 of plasmids, 2:198, 3:151 pleiotropy, 2:206 Punnett squares, 1:148, 3:33,

3:35, 3:193-194 quantitative traits, 4:3 single-gene diseases, 2:60 single-gene mutations, 1:75 STRs and, 1:189 transposable genetic elements,

4:145-146, 4:145 uniparental, 2:197 variable expressivity, 2:201, 2:204 See also Chromosomal theory of inheritance; Classical hybrid genetics; Dominant alleles; Hardy-Weinberg equilibrium; Imprinting; Mendelian genetics; Recessive alleles; Sex-linked inheritance; X-linked disorders Inheritance patterns, specific diseases and traits, 1:82 achondroplasia, 1:75-76 addiction, 1:4-5 ADHD, 1:40-41 AIS, 1:21-25

Alzheimer's disease, 1:16-18 Beckwith-Wiedemann syndrome,

2:132 behavior, 1:46-51 cancer, 1:91-92, 1:97, 1:168-170 cardiovascular disease, 1:101-103 color vision defects, 1:171-172, 3:78

cystic fibrosis, 1:200-203, 1:214,

3:142, 3:193-194 diabetes, 1:82, 1:211-212 endocrine disorders, 2:129-130 eye color, 2:32-33 founder effect, 2:36-37 fragile X syndrome, 2:39-42 hemophilia, 2:142-143, 2:144, 3:78

Huntington's disease, 2:103-105, 2:104

Marfan syndrome, 1:76 metabolic diseases, 3:38-39, 3:45 muscular dystrophies, 1:213, 2:191-192, 2:202, 2:203, 3:78, 3:83-84, 3:85, 3:86

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