Oooc oc

Gene targeting (continued)

positive and negative selection,

4:125-126 procedures, 2:4 RNA interference tools, 4:54 rodent models, 4:61, 4:124-127 therapeutic uses, 2:73 vectors, 2:71, 2:72, 4:125-126 Gene therapy, 2:74-80 advantages, 2:83 antisense nucleotide tools, 1:29,

1:30-31 disadvantages, 2:77 disease targets, 2:74 ectopic expression toxicity, 2:74 gene targeting tools, 2:73, 2:81 genomics industry role,

2:124-125 germ line vs. somatic cell therapy, 2:80-81, 2:82-83 lipid vesicle vectors, 2:76-77 longevity of gene expression,

2:77, 2:81 patent issues, 3:137 recombinant adenovirus vectors,

2:75-77, 2:78 recombinant DNA tools, 4:5-6 retrovirus vectors, 2:76 ribozyme tools, 2:79, 4:46 in utero, 2:81, 2:82 See also Stem cells, embryonic Gene therapy, ethical issues, 2:80-83

clinical trial safety, 2:81 disease treatment vs. trait enhancement, 2:82-83 embryonic stem cells, 2:6 germ line vs. somatic cell therapy, 2:80-81, 2:82-83 informed consent, 1:69, 2:81-82 success concerns, 2:83 Gene therapy, specific diseases cancer, 2:74, 2:79, 2:81 cardiovascular disease, 1:103 cystic fibrosis, 1:201, 2:81 hemophilia, 2:78, 2:80, 2:145 HIV/AIDS, 2:74, 2:80, 4:46 metabolic diseases, 3:39 muscular dystrophies, 2:75,

SCID, 2:76, 2:81, 4:75-78 sickle-cell disease, 2:78-79, 2:80, 2:138

Tay-Sachs disease, 4:102 thalassemias, 2:140 Gene trees, 4:178, 4:178

Gene walking, 1:202 Genecor, 1:73

Gene-environment interactions, 2:54-57

disease role, 1:213, 1:214 and divergence from common ancestry, 3:63 as eugenics rebuttal, 2:20, 3:81 in gene discovery studies, 2:58 and gene expression, 1:160, 2:61-62 methods for identifying, 2:56 and mutation rates, 3:99-100 patterns, 2:56-57 public health role, 3:217 quantitative trait role, 4:1-3 twins, 2:58, 4:157-158, 4:160,

4:161-162 See also Complex (polygenic) traits

Gene-environment interactions, specific diseases and traits alcoholism, 1:51

Alzheimer's disease, 1:18, 1:181, 2:56

birth defects, 1:77 cancer, 1:90, 1:92, 1:179-180 cardiovascular disease, 2:102 diabetes, 2:102

familial hypercholesterolemia, 2:57

intelligence, 2:207, 2:209-210, 2:211

phenylketonuria, 2:55-56 psychiatric disorders, 3:214 sexual orientation, 4:83-84 Genentech, 1:72, 2:125, 4:129 General cognitive ability (g), 2:207-211 See also Intelligence General Electric Corporation oil spill cleanup, 1:61 PCB pollution, 1:59 Genes, 2:50-54

additive effects, 1:178-179, 1:178 as catalysts, 3:102, 3:103 causative and susceptibility, 1:17, 1:18, 1:179, 2:55, 2:100, 2:118-120, 2:124 for energy metabolism, 2:194 as enzymes, 3:102-103 length, 2:52

minimal number required, 1:143 modifier, 3:81

multiplicative effects, 1:178-179,

1:179 mutable, 3:21 naming, 3:107-108

one gene-one enzyme model,

3:76, 3:103 one gene-one polypeptide model, 3:103

one gene-one protein model, 3:103

overlapping, 2:85-86, 3:135-136 paralogous, 2:158, 3:210 physical vs. genetic linkage,

3:5-6, 3:5 similarities to proteins, 1:52-53 size vs. mutation rate, 3:99-100 structure and function, 2:50,

See also Eukaryotes, genomes; Evolution, of genes; Genomes; Human genome; Prokaryotes, genomes; Pseudogenes; specific organisms Genesis 3000 sequencers, 1:44 Gene-specific factors activators and repressors, 4:114 function, 4:113 Genetic Alliance, 2:105 Genetic code, 2:83-87

coding and noncoding regions, 2:50, 2:52, 2:114-115, 3:82-83, 3:93, 3:99, 3:105, 3:160 codon table, 2:85, 4:137 defined, 4:137

DNA and RNA alphabets,

2:83-84, 4:135 exceptions to universal code,

2:86-87 gaps in, 2:85-86 history, 1:252-253 homologies, comparing,

2:157-158, 3:61 human, sample, 2:113 mutations, and evolution,

2:26-30, 2:27 mutations, consequences,

3:94-95 overlapping genes, 2:85-86,

3:135-136 for protein, 2:50, 2:52 punctuation lacking, 2:86 for RNA molecules, 2:52 sequence comparisons, mammals, 2:157

translation by RNA, 2:84 as universal, 1:61, 1:152, 2:21,

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment