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The MHC genes are believed to be the most allelically diverse of all human genes.

alleles particular forms of genes

Imprinting

Imprinting refers to the chemical modification of the DNA in some genes that affects how or whether those genes are expressed. One particular kind of DNA imprinting found in mammals is known as parental genomic imprinting, in which the sex of the parent from whom a gene is inherited determines how the gene is modified. While imprinting has been found in only about fifty human genes to date, some estimates suggest it may occur in several hundred more, in perhaps up to 1 percent of all genes. Imprinting defects are responsible for several human diseases, including some forms of cancer. Imprinting also occurs in other organisms, from yeast to plants to fruit flies.

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