The Puzzle of Antibody Diversity

B cells are created in the bone marrow. Many millions of different B cells are made, each containing a unique gene for the specific antibody that it (and all its descendants) will make. A group of B cells with all its descen-

hypervariable region variable region

- antibody

light chain heavy chain variable region constant region (kappa or lambda)

Antibody structure constant region (kappa or lambda)

light chain heavy chain

Invading bacterium

Antibody structure

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