Non TestisSpecific Core Histone Variants

The most studied core histone variants are the H3 variants H3.3 and CenpA, as well as the H2A variants H2AX, H2AZ and macroH2A. Although their role is not yet fully understood, these variants have been associated in somatic cells with specific chromatin structure and functions (Malik and Henikoff 2003). Most of these variants are also found in male germ cells. The H2AX variant, which is involved in DNA double-strand break (DSB) surveillance and repair, also operates during meiotic recombination...