Chromatin Architecture

Genomic imprinting may also establish a different higher-order chromatin architecture on each parental allele, as suggested by the existence of allele-specific patterns of association to the nuclear matrix at the Igf2 locus (Weber et al. 2003). The existence of a differential chromatin organization at imprinted chromosomal domains is also suggested by the observation that the human PWS/AS and IGF2/H19 loci show different meiotic recombination frequencies in the male and female germ lines (Paldi et al. 1995; Robinson and Lalande 1995). However, it remains to be clarified how these large-scale properties of imprinted domains are related to local epigenetic features at the imprinting centres.

0 0

Post a comment