Cdk

Cyclin is degraded by proteasome, leaving CDK inactive.

Cyclin-CDK complex forms, but phosphorylation on Tyr15 blocks ATP-binding site; still inactive.

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CDK Cyclin

CDK phosphorylates phosphatase, which activates more CDK.

Phosphatase ■

CDK phosphorylates DBRP, activating it. s i / I \ I \ I

Phosphorylation of Thr160 in T loop and removal of Tyr15 phosphoryl group activates cyclin-CDK manyfold.

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