FIGURE 8-22 DNA structures containing three or four DNA strands.

(a) Base-pairing patterns in one well-characterized form of triplex DNA. The Hoogsteen pair in each case is shown in red. (b) Triple-helical DNA containing two pyrimidine strands (poly(T)) and one purine strand (poly(A)) (derived from PDB ID 1BCE). The dark blue and light blue strands are antiparallel and paired by normal Watson-Crick base-pairing patterns. The third (all-pyrimidine) strand (purple) is parallel to the purine strand and paired through non-Watson-Crick hydrogen bonds. The triplex is viewed end-on, with five triplets shown. Only the triplet closest to the viewer is colored. (c) Base-pairing pattern in the guanosine tetraplex structure. (d) Two successive tetraplets from a G tetraplex structure (derived from PDB ID 1QDG), viewed end-on with the one closest to the viewer in color. (e) Possible variants in the orientation of strands in a G tetraplex.

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