Hc C

Cycloserine

Aromatic Amino Acids Are Precursors of Many Plant Substances

Phenylalanine, tyrosine, and tryptophan are converted to a variety of important compounds in plants. The rigid polymer lignin, derived from phenylalanine and tyro-sine, is second only to cellulose in abundance in plant tissues. The structure of the lignin polymer is complex and not well understood. Tryptophan is also the precursor of the plant growth hormone indole-3-acetate, or auxin (Fig. 22-28a), which has been implicated in the regulation of a wide range of biological processes in plants.

Phenylalanine and tyrosine also give rise to many commercially significant natural products, including the tannins that inhibit oxidation in wines; alkaloids such as morphine, which have potent physiological effects; and the flavoring of cinnamon oil (Fig. 22-28b), nutmeg, cloves, vanilla, cayenne pepper, and other products.

Biological Amines Are Products of Amino Acid Decarboxylation

Many important neurotransmitters are primary or secondary amines, derived from amino acids in simple pathways. In addition, some polyamines that form complexes with DNA are derived from the amino acid ornithine, a component of the urea cycle. A common denominator of many of these pathways is amino acid decarboxylation, another PLP-requiring reaction (see Fig. 18-6).

The synthesis of some neurotransmitters is illustrated in Figure 22-29. Tyrosine gives rise to a family of catecholamines that includes dopamine, norepineph-rine, and epinephrine. Levels of catecholamines are correlated with, among other things, changes in blood pressure. The neurological disorder Parkinson's disease is associated with an underproduction of dopamine, and it has traditionally been treated by administering L-dopa. Overproduction of dopamine in the brain may be linked to psychological disorders such as schizophrenia.

Glutamate decarboxylation gives rise to y-amino-butyrate (GABA), an inhibitory neurotransmitter. Its underproduction is associated with epileptic seizures.

GABA analogs are used in the treatment of epilepsy and hypertension. Levels of GABA can also be increased by administering inhibitors of the GABA-degrading enzyme GABA aminotransferase. Another important neuro-transmitter, serotonin, is derived from tryptophan in a two-step pathway.

Histidine undergoes decarboxylation to histamine, a powerful vasodilator in animal tissues. Histamine is released in large amounts as part of the allergic response, and it also stimulates acid secretion in the stomach. A growing array of pharmaceutical agents are being designed to interfere with either the synthesis or the action of histamine. A prominent example is the histamine receptor antagonist cimetidine (Tagamet), a structural analog of histamine:

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