Hn Nh


FIGURE 21-1 The acetyl-CoA carboxylase reaction. Acetyl-CoA carboxylase has three functional regions: biotin carrier protein (gray); biotin carboxylase, which activates CO2 by attaching it to a nitrogen in the biotin ring in an ATP-dependent reaction (see Fig. 16-16); and transcarboxylase, which transfers activated CO2 (shaded green) from


biotin to acetyl-CoA, producing malonyl-CoA. The long, flexible biotin arm carries the activated CO2 from the biotin carboxylase region to the transcarboxylase active site, as shown in the diagrams below the reaction arrows. The active enzyme in each step is shaded blue.

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