Vvi

Fructose 6- + ATP-phosphate

Fructose 1,6- + ADP bisphosphate

citrate fructose 2,6-bisphosphate

All other glycolytic tissues

FIGURE 15-19 Regulation of pyruvate kinase. The enzyme is al-losterically inhibited by ATP, acetyl-CoA, and long-chain fatty acids (all signs of an abundant energy supply), and the accumulation of fructose 1,6-bisphosphate triggers its activation. Accumulation of alanine, which can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis. The liver isozyme (L form) is also regulated hormonally; glucagon

All other glycolytic tissues

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