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2. Evidence for a Lipid Bilayer In 1925, E. Gorter and F. Grendel used an apparatus like that described in Problem 1 to determine the surface area of a lipid monolayer formed by lipids extracted from erythrocytes of several animal species. They used a microscope to measure the dimensions of individual cells, from which they calculated the average surface area of one erythrocyte. They obtained the data shown in the

Force applied here to compress

Force applied here to compress

table. Were these investigators justified in concluding that "chromocytes [erythrocytes] are covered by a layer of fatty substances that is two molecules thick" (i.e., a lipid bilayer)?

Total surface

Volume of Number area of lipid Total surface packed of cells monolayer area of one Animal cells (mL) (per mm3) from cells (m2) cell (^m2)

Dog

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