Metabolic Control Analysis Has Been Applied to Carbohydrate Metabolism with Surprising Results

Metabolic control analysis provides a framework within which we can think quantitatively about regulation, interpret the significance of the regulatory properties of each enzyme in a pathway, identify the steps that most affect the flux through the pathway, and distinguish between regulatory mechanisms that act to maintain metabolite concentrations and control mechanisms that actually alter the flux through the pathway. Analysis of the glycolytic pathway in yeast, for example, has

FIGURE 15-35 Elasticity coefficient, e, of an enzyme with typical Michaelis-Menten kinetics. At substrate concentrations far below the Km, each increase in [S] produces a correspondingly large increase in the reaction velocity, v. For this region of the curve, the enzyme has an elasticity, e, of about 1.0. At [S] >> Km, increasing [S] has little effect on v; e here is close to 0.0.

FIGURE 15-35 Elasticity coefficient, e, of an enzyme with typical Michaelis-Menten kinetics. At substrate concentrations far below the Km, each increase in [S] produces a correspondingly large increase in the reaction velocity, v. For this region of the curve, the enzyme has an elasticity, e, of about 1.0. At [S] >> Km, increasing [S] has little effect on v; e here is close to 0.0.

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