O

-N—C—N-H H Dicyclohexylurea byproduct

Reactions to (T) repeated as necessary

Completed peptide is deprotected as in reaction ; HF cleaves ester linkage between peptide and resin.

TABLE 3-8 Effect of Stepwise Yield on Overall Yield in Peptide Synthesis

Number of residues in the final polypeptide

Overall yield of final peptide (%) when the yield of each step is:

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