P

P-Enzn

P-Enzn

Inside

FIGURE 11-37 Postulated mechanism of Na+ and K+ transport by the Na+K+ ATPase.

Transporter releases 3 Na+ to the outside and binds 2 K+ from the outside of the cell.

Inside

Dephosphorylation favors EnzI.

Transporter releases 2 K+ to the inside.

Outside

FIGURE 11-37 Postulated mechanism of Na+ and K+ transport by the Na+K+ ATPase.

to the protein so as to lock it into a position in which the ion-binding sites are permanently accessible from both sides, converting the transporter into a nonspecific ion channel. This allows exit of K+ from cells and deflates the (essential) ion gradient across the plasma membrane, which accounts for the high toxicity of this compound.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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