The Oxidative Phase Produces Pentose Phosphates and NADPH

The first reaction of the pentose phosphate pathway (Fig. 14-21) is the oxidation of glucose 6-phosphate by glucose 6-phosphate dehydrogenase (G6PD) to form 6-phosphoglucono-S-lactone, an intramolecular ester. NADP+ is the electron acceptor, and the overall equilibrium lies far in the direction of NADPH formation. The lactone is hydrolyzed to the free acid 6-phos-phogluconate by a specific lactonase, then 6-phospho-gluconate undergoes oxidation and decarboxylation by 6-phosphogluconate dehydrogenase to form the ke-topentose ribulose 5-phosphate. This reaction generates

Glucose 6-phosphate

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