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Farhy LS, Straume M, Johnson ML, Kovatchev BP, Veldhuis JD 2001 A construct of interactive feedback control of the GH axis in the male. Am J Physiol 281:R38—R51 Govoni S, Memo M, Saiani L, Spano PF, Trabucchi M 1980 Impairment of brain neurotransmitter receptor in aged rats. In: Mechanisms of aging and development, chapter 1—2. Elsevier Sequoia, Lausanne, p 39—46 Iranmanesh A, Veldhuis JD, Carlson EC et al 1990 Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 71:73—78 Iranmanesh A, Mulligan T, Veldhuis JD 1999 Mechanisms subserving the physiological nocturnal relative hyperprolactinaemia of healthy older men: dual decline in prolactin secretory burst mass and basal release with preservation of pulse duration, pulse frequency, and interpulse interval: a general clinical research center study. J Clin Endocrinol Metab


Keenan DM, Veldhuis JD 1998 A biomathematical model of time-delayed feedback in the human male hypothalamic—pituitary—Leydig cell axis. Am J Physiol 275:E157—E176 Keenan DM, Veldhuis JD 2001 Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol Regul Integr Comp Physiol 280:R1755—R1771 Keenan DM, Sun W, Veldhuis JD 2000 A stochastic biomathematical model of the male reproductive hormone system. SIAM J Appl Math 61:934—965 Mulligan T, Iranmanesh A, Kerzner R, Demers LW, Veldhuis JD 1999 Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig cell) defects in the healthy aging male gonadotropic axis. Eur J Endocrinol 141:257—266 Pincus SM, Mulligan T, Iranmanesh A, Georghiu S, Godschalk M, Veldhuis JD 1996 Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc Natl Acad Sci USA 93:14100—14105 Straume M, Chen L, Johnson ML, Veldhuis JD 1995 Systems-level analysis of physiological regulation interactions controlling complex secretory dynamics of growth hormone axis: a connectionist network model. Methods Neurosci 28:270—310 Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, Veldhuis JD 1988 Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9:3—37 Veldhuis JD 1999a Male hypothalamic-pituitary-gonadal axis. In: Yen SSC, Jaffe RB, Barbieri

RL (eds) Reproductive Endocrinology. W.B. Saunders Co., Philadelphia p 622—631 Veldhuis JD 1999b Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamo-pituitary-gonadal axis. J Androl 20:1—17 Veldhuis JD, Dufau ML 1987 Estradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man. J Clin Invest 80:631—638 Veldhuis JD, Rogol AD, Samojlik E, Ertel NH 1984 Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man. J Clin Invest 74:47—55 Zwart AD, Urban RJ, Odell WD, Veldhuis JD 1996 Contrasts in the gonadotropin-releasing dose—response relationships for luteinizing hormone, follicle-stimulating hormone, and a subunit release in young versus older men: appraisal with high specificity immunoradiatric assay and deconvolution analysis. Eur J Endocrinol 135:399—406

Endocrine Facets of Ageing.

Novartis 242

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