Advances in GHRH, GHRP and SS peptide chemistry, receptorology and neuroregulatory physiology now create a unique platform for more informative and insightful clinical studies of the mechanisms of testosterone's control of the ageing human GH/IGF1 axis. We suggest that the relatively hyposomatotropic and hypoandrogaemic older male should afford an excellent clinical context in which to explore such issues. In addition, based on the cardinal role of sex steroid hormones in sustaining GH secretion throughout the adult human lifetime (Giustina & Veldhuis 1998), such studies should also provide significant corollary insights into the regulatory pathophysiology of the GH/IGF1 axis during early puberty and other hypogonadal states.

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