In this chapter we have described the changes in the male reproductive axis with ageing in the BN rat as a model for human reproductive dysfunction. We have shown that the reproductive axis in the rat sustained dual hits at the testis and the hypothalamus. We showed that these hits caused an accelerated neuronal and germ cell apoptosis presumably as a result of oxidative damage by excessive accumulation of the inducible NOS. The dual dysfunction at both the testicular and hypothalamic regions possibly resulted in impaired Leydig cell function and decreased spermatogenesis characteristic of male reproductive ageing in men.

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