Serologic tests for Mycoplasma pneumoniae include enzyme-linked immunosorbent assay (ELISA), complement fixation, and cold agglutinins; for Chlamydia pneumoniae they include microimmunofluorescence; and for Legionella spp. immunofluorescence assay.66 However, results from serologic tests to diagnose "atypical" pathogens often return after the patient has been discharged and do not impact the treatment plan.67 This is particularly challenging for SARS where real-time diagnosis is needed.

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