O

N-R4

Terphenyl scaffold

Terephthalamide scaffold

Terphenyl scaffold

Bcl-xL-inhibiting terphenyl

Bcl-xL-inhibiting terephthalamide

Fig. 8.5 Terphenyl and terephthalamide scaffolds and Bcl-xL inhibiting derivatives.

Bcl-xL-inhibiting terphenyl

Bcl-xL-inhibiting terephthalamide

Fig. 8.5 Terphenyl and terephthalamide scaffolds and Bcl-xL inhibiting derivatives.

spatial arrangement of substituted i, i + 4 and i + 7 positions of short a-helical segments [142]. Therefore, the terphenyl scaffold has been utilized to target helix recognizing proteins [142-146]. The terphenyl ring systems have been synthesized using Suzuki [143, 144] or Negishi [142] couplings. Low water solubility of terphenyl foldamers has led to the replacement of the terminal rings with carbox-yamides to give terephthalamide derivatives with improved water solubility (see Fig. 8.5) [147, 148].

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