Apolipoproteins arise from local synthesis or filtration from plasma, although the respective amount remains unclear. According to current views, apolipoprotein E (apoE) is the main apolipoprotein produced and secreted by astrocytes within the brain parenchyma. ApoE is presumably involved in the redistribution of lipids among cells. Other apolipoproteins appear to be involved in brain lipid transport and homeostasis, such as ApoJ and ApoD. ApoD is found mainly in oligodendrocytes and astrocytes. Irregular lipoprotein metabolism, possibly related to special isoforms, may be involved in several neurodegenerative diseases, especially Alzheimer's disease.

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