The authors thank Drs. Jamuna Subramaniam, Lio Tessarollo, Valeria Culotta, Jonathan Gitlin, David Borchelt, Lee Martin, Michael Lee, Sam Sisodia, Dave Cornblath, Bruce Rabin, Vassilis Koliatsos, Glen Lin, Tom Crawford, Mark Becher, Paul Hoffman, Ann Bergin, Don Cleveland, Jack Griffin, Lucie Brujin, and Carlos Pardo for their helpful discussions and contributions to some of the work mentioned in this text. Aspects of this work were supported by grants from the U.S. Public Health Service (NIH NS 37771, NS 10580, NS 20471, AG 05146, AG 07914, AG 10491, AG 10480, AG 14248 and AG 67914).

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