Axon Outgrowth and Tract Formation

Axon outgrowth is an early feature of neuronal differentiation and may be quite advanced even as neurons are migrating. Many axons are commissural, crossing the midline to course in axon tracts and innervate synaptic targets on the opposite side of the neuraxis. Once axons begin to project longitudinally, they tend to fasciculate into bundles that are located predominantly either near the pial surface or adjacent to the raphe. Two major axon bundles are present at early stages of hindbrain development: a medial longitudinal fascicle (mlf) and a lateral longitudinal

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