Csf

CSF is continuously produced at the rate of approximately 500 cc/day. The total volume of CSF is approximately 150 ml at any time. CSF is formed as an ultrafiltrate from the villi of the choroid plexus and production is partially regulated by the enzymes sodium potassium ATPase and carbonic anhydrase. One function of the CSF appears to be mechanical, serving as a kind of water jacket for the spinal cord and brain, protecting them from potentially injurious blows to the spinal column and skull and acute changes in venous pressure. CSF hydraulically balances the brain within the skull.

The CSF is also believed to serve to remove waste metabolites of cerebral metabolism and may act as a pathway for distribution of peptides and hormones within the nervous system. This possible function has never been adequately explored.

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