B GABA as a Paracrine Reset Signal

GABA-producing cells increase GAD67 and GAD67 mRNA levels in response to injury, whereas GAD65 and its mRNA are usually unchanged. Injuries that produce increased GAD67 include chemical lesions of the substantia nigra and hippocampus, neuroleptic drugs, spinal cord transection, and acute stress. The increase in GAD67 can be observed as soon as 1 hr after insult, implicating immediate early genes in GAD67 regulation.

Most GAD67 is not associated with synapses, and GAD67 may be responsible for carrier-mediated GABA release. This direct release of cytoplasmic

Aspergers Answers Revealed

Aspergers Answers Revealed

Learn How to Help, Understand amp Cope with your Aspergers Child from a UK Chartered Educational Psychologist. Before beginning any practice relating to Aspergers it is highly recommended that you first obtain the consent and advice of a qualified health,education or social care professional.

Get My Free Ebook

Post a comment