B GABA as a Paracrine Reset Signal

GABA-producing cells increase GAD67 and GAD67 mRNA levels in response to injury, whereas GAD65 and its mRNA are usually unchanged. Injuries that produce increased GAD67 include chemical lesions of the substantia nigra and hippocampus, neuroleptic drugs, spinal cord transection, and acute stress. The increase in GAD67 can be observed as soon as 1 hr after insult, implicating immediate early genes in GAD67 regulation.

Most GAD67 is not associated with synapses, and GAD67 may be responsible for carrier-mediated GABA release. This direct release of cytoplasmic

Understanding And Treating Autism

Understanding And Treating Autism

Whenever a doctor informs the parents that their child is suffering with Autism, the first & foremost question that is thrown over him is - How did it happen? How did my child get this disease? Well, there is no definite answer to what are the exact causes of Autism.

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