Huntingtons Disease HD

HD is an autosomal-dominant genetic disorder marked by initial abnormal choreiform (dancelike) movements, slowed voluntary movements, depressive and manic emotional disturbances, and eventual dementia. HD manifests in an insidious onset, usually in young to middle adulthood. The dementia of HD is characterized neuropsychologically by impaired attention and concentration, executive function deficits, and impaired encoding and retrieval of new information. However, if care is taken to make sure that the person with HD adequately encodes the information (e.g., by having the individual semantically categorize it) and procedures are used that do not require effortful retrieval strategies (e.g., recognition memory rather than a free recall task), then it can be shown that the retention of new information is more intact in HD than in AD patients with comparable overall dementia severity. The neuropathology of HD includes cell loss and atrophy that begins in the medial caudate nucleus and eventually includes the entire caudate and putamen. Some degree of cortical atrophy is also typically seen in the brains of persons with HD at autopsy.

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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