Inflammatory Factors

HIV probably enters the central nervous system within macrophages from the periphery, thereby establishing an intracerebral focus of infection in closely related microglia. Microglia (immune cells within the brain closely related to macrophages) may become infected, and these two cell populations feature prominently in two of the hallmark changes found in the brain of persons dying with HIV encephalitis—microglial nodules and multinucleated giant cells (Fig. 2). Astrocytes may also become activated; in addition to producing abnormal quantities of various molecules

Table II

Currently Available Antiretroviral Medications

Table II

Currently Available Antiretroviral Medications

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