Lesion Momentum

Individuals who present with low-grade tumors that have been present for many years may have no detectable changes in brain function due to cerebral plasticity and reorganization, whereas those with very rapidly growing tumors may have widespread impairment due to mass effect on adjacent brain regions. Patients with gliomatosis cerebri, a condition in which tumor cells diffusely infiltrate large brain regions, may have few focal impairments since neuronal function is not substantially altered. Patients with metastatic brain tumors may also present without focal or severe deficits since neuronal tissue is displaced by the lesion and not necessarily damaged.

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