Ligand Gated Ion Channels

Ligand-gated ion channels are activated upon the binding of a neurotransmitter to the ion channel and are involved in fast synaptic transmisssion in the nervous system. Many of the ion channels in Table II have a wide tissue distribution outside of the nervous system and have other functions beyond synaptic transmission. These neurotransmitters include acetyl-choline, g-aminobutyric acid (GABA), glycine, glutamate, and serotonin (5-hydroxytryptophan), and the ion channels are more commonly referred to as receptors. Several of these neurotransmitters also activate a second distinct type of receptor. This second receptor type is a heptahelical receptor that produces intracellular second messengers through the modulation of G proteins. Most commonly in the context of glutamate receptors, the ligand-gated ion channel is referred to as an ionotropic receptor, whereas the G

Ion channel Ion selectivity



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