Lineage and Development

In the human brain, ependymoglial cells are thought to be derived from the developing neuroepithelium along a caudal-to-rostral gradient. Radial glial cells are the first subtype of neuroglia to appear during human fetal brain development. They stain intensely with GFAP and nestin early in development but lose immunoreactivity with time. It is thought that epen-dymoglia arise from a radial progenitor in a pathway that can also give rise to astrocytes. The radial progenitors differentiate into radial glial cells, which can then morphologically transform into the subtypes of ependymoglial cells mentioned earlier as well as into astrocytes.

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