Specific Uptake

As described earlier, choline is not synthesized in nervous tissue. The choline produced by the hydrolysis of ACh by acetylcholinesterase is taken back up into the presynaptic neuron by a transport mechanism specific to cholinergic neurons and is used for the resynthesis of transmitter. As also described previously for glutamate, the small-molecule neurotransmitters are taken up by high-affinity transporter mechanisms. Uptake by means of specific transport is the most important way classical transmitter molecules are removed from the synaptic cleft. Neuropeptides are not taken back up into the neuron and are removed by diffusion and by cleavage by extracellular peptidases.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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