Fetal Mesencephalic Transplants

The majority of current clinical trials are based on using human fetal mesencephalic tissues from first trimester abortion specimens. The use of tissue fragments is still popular. The clinical outcome of some of the studies discussed later depends more on the surgical technique and underlying host condition rather than the quality of the donor tissue. The autopsy studies are few, and the in vivo assessment of the grafts is still limited by the accuracy of positron emission tomography (PET). Nevertheless, clinical symptoms do appear to improve in some patients, often for extended periods of time, and the overall results are encouraging. The investigators agree on the need for standardized tissue processing and

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