C

Figure 3 Prevention of endothelial cell NO-induced phosphatidylserine (PS) externalization. A representative figure is shown of cerebral endothelial cells that were identified for PS externalization following exposure to NO with fluorescent microscopy. (A) Untreated endothelial cells (control) are without significant PS exposure. (B) Endothelial cells were exposed to NO and PS exposure was assessed 24 hr later. In the presence of NO, PS was present in approximately 80% of the endothelial cells examined. (C) Treatment with the metabotropic glutamate receptor agonist DHPG significantly prevented endothelial cell injury and cellular membrane PS exposure induced by NO exposure.

their cation modulators have been identified that may contribute to acute neuronal injury. As an alternative mechanism, free radical regulation of intracellular pH can also influence PCD induction. It is hoped that further knowledge of these pathways will assist in the development of therapeutic regiments against organic brain disease.

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