C

Figure 3 Prevention of endothelial cell NO-induced phosphatidylserine (PS) externalization. A representative figure is shown of cerebral endothelial cells that were identified for PS externalization following exposure to NO with fluorescent microscopy. (A) Untreated endothelial cells (control) are without significant PS exposure. (B) Endothelial cells were exposed to NO and PS exposure was assessed 24 hr later. In the presence of NO, PS was present in approximately 80% of the endothelial cells examined. (C) Treatment with the metabotropic glutamate receptor agonist DHPG significantly prevented endothelial cell injury and cellular membrane PS exposure induced by NO exposure.

their cation modulators have been identified that may contribute to acute neuronal injury. As an alternative mechanism, free radical regulation of intracellular pH can also influence PCD induction. It is hoped that further knowledge of these pathways will assist in the development of therapeutic regiments against organic brain disease.

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment