Newly described in the past decade, CADASIL (cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a genetic disorder of cerebral white matter in which ischemia and infarction slowly erode neurologic and neurobe-havioral function. The disease is known to be caused by one of several mutations in the notch 3 region of chromosome 19, and characteristic granular osmio-philic material is seen in the walls of arterioles on electron microscopy. The clinical course begins in adulthood and may be characterized by neuropsychia-tric dysfunction, migraine, stroke, and dementia. MRI scans regularly show leukoencephalopathy, even in individuals who are asymptomatic. Treatment is limited to supportive care and prevention of cerebro-vascular risk factors that can exacerbate the process.

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Naturally Cure Your Headaches

Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?

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