Cerebral Amyloid Angiopathy

This disorder, often but not always seen in patients with Alzheimer's disease (AD), has long been known to be a cause of lobar hemorrhage. It has recently been recognized that deposition of amyloid in cerebral arterioles may also lead to leukoencephalopathy, presumably because of hypoperfusion in arterioles supplying the deep white matter. Thus, white matter changes that are sometimes seen in patients with AD may be related to this condition, and in other patients, the clinical and neuropathologic picture may resemble that of Binswanger's disease.



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