Chronic Lyme Encephalopathy

Figure 1 Representative MRI scan (left), SPECT image (center), and superimposed MRI/SPECT image (right) in a normal subject and in a patient with objective evidence of LE. The dark areas correspond to lower and the light areas to higher perfusion. (See color insert in Volume 1).

deficits described previously. Unfortunately, hypoperfusion in these brain regions is not specific to Lyme disease. Similar SPECT findings have been reported in other conditions that have symptoms similar to LE, such as depression and chronic fatigue syndrome. Although some investigators argue that the pattern of hypoperfusion in LE may differ from that seen in other disorders, current quantitative SPECT studies have not yet been done. Therefore, SPECT alone is not sufficient in diagnosing LE.

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