The Vomiting Center

The vomiting center was an area originally discovered by electrically stimulating brain stem medullary structures to induce emesis. However, it is now more

Figure 6 Diagram of the vestibuloautonomic pathways and the interactions with higher brain function relevant to emesis. Adapted from Babalan and Porter (1998) and Furman et a/.(1998). Clinical evidence that the vestibular system participates in autonomic control. J. Vestibular Res. 8(1), 27-34. Reproduced by permission of Elsevier Science.

Figure 6 Diagram of the vestibuloautonomic pathways and the interactions with higher brain function relevant to emesis. Adapted from Babalan and Porter (1998) and Furman et a/.(1998). Clinical evidence that the vestibular system participates in autonomic control. J. Vestibular Res. 8(1), 27-34. Reproduced by permission of Elsevier Science.

accurately described as a collection of effector nuclei rather than a discrete brain area. The vomiting center receives major inputs from the chemoreceptor trigger zone, the nucleus tractus solitarius, the vestibular nucleus, a vagal and sympathetic input from the gut, and input from the cardiovascular system and a number of limbic brain nuclei, e.g., the olfactory tubercle, amygdala, hypothalamus, and ventral thalamic nucleus. Electrical stimulation of all of these structures can induce emesis. The latter nuclei may be involved in olfactory, emotional-anticipatory, hormonal-stress, and pain-induced vomiting, respectively.

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