Brain Mechanisms and Nausea

Finally, the brain regions that produce the sensation of nausea have been difficult to assess; nausea is a subjective human experience, and reliable animal models are not available. However, noninvasive magnetic source imaging in humans has revealed that neuronal activation occurs in the cortex in the inferior frontal gyrus in volunteers made nauseous with ipecacuanha or vestibular stimulation: the activation caused by ipecacuanha (but not vestibular) was antagonized by ondansetron. This brain area may be important in the perception or sensation of nausea (Fig. 7).

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