For many years, the endogenous ligand for the mu opioid receptor was unknown. The recent identification of two tetrapeptides, endomorphin 1 and endo-morphin 2, has resolved this issue. These peptides have a very interesting pharmacology and display the selectivity expected of a morphine-like, or mu, opioid peptide. It is assumed that the two peptides are also generated from a larger precursor, but this protein has not been identified. Although the evidence supporting the endomorphins is quite strong, the identification of its precursor is needed to fully establish its importance pharmacologically.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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